Author

Qiong-Qiong Hou

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Oct 2026

Liver-Targeted DGAT2 siRNA Ameliorates Steatosis and Fibrosis in a High-Fat Diet-Induced MASH Mouse Model.

Diacylglycerol O-acyltransferase 2 (DGAT2), a key enzyme in hepatic triglyceride (TG) synthesis, is considered a promising therapeutic target for metabolic dysfunction-associated steatohepatitis (MASH). Small interfering RNAs (siRNAs) targeting conserved regions of human and mouse DGAT2 mRNA were designed, synthesized,...

En-Hua Zhang, Wei Zheng, Yi-Zhe Li et al. · Journal of drug targeting (P... · 0 citations

Sep 2026

Lipid-conjugated siRNA targeting SARM1 enables CNS silencing and mitigates alzheimer-like phenotypes.

RNA interference (RNAi) therapeutics have achieved clinical success in liver disease, but their application to central nervous system (CNS) disorders remains limited. Here, we developed a lipid-conjugated siRNA to silence sterile alpha and TIR motif-containing protein 1 (SARM1), a key executor of axon degeneration asso...

Ying Cai, Qiong-Qiong Hou, Zi-Hui Cheng et al. · Bioorganic chemistry (Print) · 0 citations

Review Jul 2026

Molecular Mechanisms and Therapeutic Strategies in Parkinson's Disease: From Pathogenic Signaling to Drug Development.

This review systematically summarizes the molecular mechanisms and biomarkers associated with PD, outlines current symptomatic treatments, and discusses emerging therapeutic candidates in clinical development, with particular emphasis on disease-modifying strategies.

Zhihui Shen, Jiaxin Cheng, Linlin Wang et al. · Current Neuropharmacology · 0 citations