Purpose Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for...
Chan Zhu, Yi-Jing Zhang, Pan-Wei Hu et al.· Journal of Food and Drug Ana...· 0 citations
Metabolic syndrome (MetS) is a clinical syndrome primarily characterized by insulin resistance, integrating central obesity, hyperglycemia, hypertension and dyslipidemia. It is associated with increased risks of type 2 diabetes mellitus, non-alcoholic fatty liver disease and atherosclerosis. Due to its high prevalence,...
Jia-Lin Zhong, Mao-Fu Zhang, Ya-Fang Zheng et al.· International Journal of Mol...· 0 citations
Maturity-onset diabetes of the young (MODY) is the most common form of monogenic diabetes, with genetic and clinical heterogeneity emerging as significant challenges. Despite growing scholarly attention to MODY research, the overall knowledge structure, research priorities, and developmental trends in this field...
Cui-Cui Gong, Ya-Sheng Deng, Huakang Li et al.· Orphanet Journal of Rare Dis...· 0 citations
Polycystic ovary syndrome (PCOS) is a common endocrine disorder influenced by genetic and environmental factors, yet the molecular mechanisms linking endocrine-disrupting chemicals (EDCs) to ovarian dysfunction remain unclear. Here, we establish a letrozole-induced PCOS-like rat model and integrate bulk RNA-seq, single...
Chan Zhu, Xian-Liang Qiu, Hong Yang et al.· Journal of Steroid Biochemis...· 0 citations
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