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Open access Sep 2026

Identification of CA2 as a potential candidate gene involved in the therapeutic effect of Huatan Huoxue decoction on polycystic ovary syndrome: An integrated study of network pharmacology, Mendelian randomization, and experimental validation

Purpose Huatan Huoxue decoction (HTHXD) is effective in treating polycystic ovary syndrome (PCOS); however, its underlying mechanisms of action remain unclear. Gene targets were obtained through Mendelian randomization (MR) analysis using druggable genes from public databases and genome-wide association study data for...

Chan Zhu, Yi-Jing Zhang, Pan-Wei Hu et al. · 0 citations
Review Open access Sep 2026

Programmed cell death in metabolic syndrome: From molecular mechanisms to therapeutic strategies (Review)

Metabolic syndrome (MetS) is a clinical syndrome primarily characterized by insulin resistance, integrating central obesity, hyperglycemia, hypertension and dyslipidemia. It is associated with increased risks of type 2 diabetes mellitus, non-alcoholic fatty liver disease and atherosclerosis. Due to its high prevalence,...

Jia-Lin Zhong, Mao-Fu Zhang, Ya-Fang Zheng et al. · 0 citations
Open access Sep 2026

Bibliometric mapping of scientific production on maturity-onset diabetes of the young: evolution, hotspots, and future directions

Maturity-onset diabetes of the young (MODY) is the most common form of monogenic diabetes, with genetic and clinical heterogeneity emerging as significant challenges. Despite growing scholarly attention to MODY research, the overall knowledge structure, research priorities, and developmental trends in this field...

Cui-Cui Gong, Ya-Sheng Deng, Huakang Li et al. · 0 citations
Aug 2026

Environmental Endocrine Disruptors Activate CBX2 to Disrupt Cholesterol Homeostasis in PCOS.

Polycystic ovary syndrome (PCOS) is a common endocrine disorder influenced by genetic and environmental factors, yet the molecular mechanisms linking endocrine-disrupting chemicals (EDCs) to ovarian dysfunction remain unclear. Here, we establish a letrozole-induced PCOS-like rat model and integrate bulk RNA-seq, single...

Chan Zhu, Xian-Liang Qiu, Hong Yang et al. · 0 citations

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