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Qiu-Yue Wang

2 papers indexed here

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Review Open access Aug 2026

The role of PANoptosis in diabetes and its complications: mechanisms and therapeutic prospects

Diabetes mellitus and its complications are chronic inflammatory diseases driven by metabolic stress. PANoptosis is a recently defined inflammatory lytic cell death pathway that integrates key features of pyroptosis, apoptosis, and necroptosis, and is orchestrated by the PANoptosome complex. Emerging evidence indicates...

Jin-Hong Yan, Qiu-Yue Wang, Fenqin Chen · 0 citations
Aug 2026

Metformin Alleviates High Glucose-Induced Pyroptosis and Inflammatory Responses in HK-2 Cells via SIRT1-Associated Regulation of the TXNIP/NLRP3 Pathway.

BACKGROUND Diabetic kidney disease (DKD) is a major cause of renal failure and end-stage renal disease. Pyroptosis, a Gasdermin-dependent inflammatory form of programmed cell death, has been implicated in DKD progression. Metformin has shown renoprotective effects in DKD; however, the underlying mechanisms remain uncle...

Shu-Yu Shi, Bing Wang, Yang Zhou et al. · 0 citations

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