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Author

Qiwei Zhou

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Sep 2026

A Click-Triggered Bioorthogonal Strategy for Dual Activation of Covalent Warheads and Reporter Payloads

Michael acceptors are indispensable electrophilic motifs in chemical biology and covalent drug discovery, yet their intrinsic “always-on” reactivity frequently causes off-target modification and limits therapeutic precision. Here we report a bioorthogonal strategy for externally controlling Michael acceptor reactivit...

Xiao-Wei Xu, Yang-Fei Shi, Yan Zhao et al. · 0 citations
Jul 2026

Pathology-Responsive Self-Assembling Hydrogel Enabling Spatiotemporally Controlled Exosome Release and Redox Regulation for Intervertebral Disc Regeneration.

A pathology-adaptive self-assembling hydrogel that exploits dynamically varying catabolic enzyme activity to trigger on-demand delivery of antioxidant molecules and bioactive extracellular vesicles leads to significant structural and functional recovery of the damaged disc, as strongly evidenced in vivo animal studies.

Zhan Gao, Gan Lyu, Qiwei Zhou et al. · 0 citations

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