Topological imaging of single-cell CAF heterogeneity for predicting prognosis and adjuvant chemotherapy benefit in pancreatic cancer.
PURPOSE Cancer-associated fibroblasts (CAFs) are central drivers of PDAC progression and therapeutic resistance, yet their preoperative clinical utility remains unexplored. We aimed to translate single-cell CAF heterogeneity into a CT-based framework for preoperative risk stratification and adjuvant chemotherapy strati...