Author

Quaid Morris

2 papers indexed here

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Open access Aug 2026

An expanded codebook of human transcription factor DNA-binding specificity

Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs1. Furthermore, even for well-characterized TFs, it remains controversial the degree to which motif...

A. Jolma, Kaitlin U. Laverty, Ali Fathi et al. · Nature · 3 citations

Open access Aug 2026

Extensive binding of poorly characterized human transcription factors to genomic dark matter

It is found that induction of TPRX1, a known regulator of zygotic preimplantation, leads to chromatin opening at many of its binding sites in the dark matter genome, suggesting that the genome encodes many putative transcription factors.

Rozita Razavi, Ali Fathi, Isaac Yellan et al. · Nature Communications · 3 citations