Unraveling the bidirectional interplay of the gut microbiota with chemotherapy and radiotherapy in colorectal cancer: from pathogenesis to probiotic interventions.
Colorectal cancer remains a leading cause of cancer-related mortality worldwide. While chemotherapy and radiotherapy serve as a cornerstone of treatment, their clinical efficacy is frequently compromised by therapeutic resistance and gastrointestinal toxicity. Accumulating evidence indicates that the gut microbiota is...