Integration of Network Toxicology and Machine Learning to Prioritize Candidate Molecular Features Associated with NNK-Related Lung Cancer
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific nitrosamine implicated in tobacco-related lung carcinogenesis. Its biological effects in vivo depend substantially on metabolic conversion to NNAL and cytochrome P450-mediated formation of reactive intermediates. In this study, predicted NNK-a...