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Quentin Leprat

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Open access Sep 2026

HIF-1α-ASS1 axis drives reprogramming of arginine metabolism controls hepatic stellate cell activation in hepatic fibrosis.

ABRL8301 acts as a pharmacologic inducer of ASS1 and arginine biosynthesis, inhibiting EMT and fibrotic progression while enhancing anticancer therapy and support ABRL8301 as a promising antifibrotic and tumor-sensitizing agent in hepatic fibrosis.

Seungeun Lee, Yeonhwa Song, Sanghwa Kim et al. · 0 citations

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