Qun-Lun Shen

DeSPA uncovers genes with cross-state spatial pattern remodeling and coordinated spatial programs across multi-slice spatial transcriptomics atlases

Spatial transcriptomics increasingly generates multi-slice atlases spanning developmental, regenerative, and disease-associated states. Identifying genes with spatial pattern remodeling across these states is essential for understanding tissue reorganization and the underlying gene programs, yet few existing methods sy...