SIRT1–Redox Crosstalk in Aging: Adaptive Capacity and Cellular State Transitions
Aging gradually reduces the ability of cells to maintain and restore homeostasis under metabolic and oxidative stress. Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that regulates metabolism, mitochondrial function, inflammatory signaling, and cellular stress responses. Its activity depends on NAD+ availability, r...