Open access
Aug 2026
MicroRNA-34a suppresses KLF2 to promote pathological angiogenesis through the CXCR4/CXCL12 pathway in age-related macular degeneration.
A causal link between the age-related miR-34a and neovascularization in AMD is established and miR-34a directly targets and inhibits the transcription factor KLF2, thereby upregulating the proangiogenic factors CXCR4 and CXCL12.
Jason J. Colasanti, A. Santeford, Joseph B. Lin et al.
· Proceedings of the National... · 1 citation