R. Au

Linguistic features from paragraph recall are markers of cognitive impairment.

A multiancestry polygenic risk score for Alzheimer’s disease is associated with cognitive decline and neuropathological hallmarks in diverse populations

Previously derived polygenic risk scores (PRSs) for Alzheimer’s disease (AD) perform inconsistently across diverse ancestries. We developed an APOE-independent multiancestry AD PRS using genome-wide association study summary statistics applied to European ancestry, African American, Caribbean Hispanic and East Asian co...

Novel Plasma Proteins Associated With Alzheimer’s Disease Risk in APOE ε4 Carriers and Non-carriers

Background Whether plasma protein associations with Alzheimer’s disease (AD) differ by genetic risk remains unclear. Methods We studied 18,212 UK Biobank participants aged ≥ 60 years with Olink Explore 3072 proteomic data, APOE genotypes, and AD polygenic risk scores. Protein-by-genetic risk interactions were screened,...

Associations Between Smartwatch-Derived Measures and Cognitive Function: Findings From the Electronic Framingham Heart Study.

BACKGROUND Daily heart rate (HR) and physical activity are biomarkers of cardiovascular disease. A smartwatch-derived metric, daily HR per step (DHRPS), has also been associated with cardiovascular disease. Integrating smartwatch data with neuropsychological assessments in older adults makes it possible to capture subc...

Sleep electroencephalography-derived brain health and long-term cognitive decline in community-dwelling adults

Associations between a sleep-derived brain health score in mid-to-late life and subsequent cognitive decline in memory, executive function, and language are demonstrated, providing additional support for the potential utility of using this data-driven sleep score as a digital biomarker for the risk of cognitive decline...

How Life-Course Trajectories of Physical Activity Track With Cognitive Decline.

It is suggested that sustaining PA in mid-to-late life and preventing later life declines may help mitigate cognitive decline with aging.