Transportin-3 (TNPO3) is a HEAT-repeat nuclear transport receptor that mediates nuclear import of serine/arginine-rich (SR) proteins and interacts with Ran GTPase during nuclear transport cycle. Although structures of several TNPO3 complexes are available, how ligand binding modulates the conformational landscape of th...
Sonali Chatterjee, Atanu Maity, R. Bahadur· Biophysical Journal· 0 citations
Transcription factors (TFs) regulate gene expression by controlling the recruitment of transcriptional machinery to regulatory regions of the genome. Nearly 10% of the human genome encodes TFs, making them one of the largest protein families. Despite their central roles in gene regulation, TFs are historically consider...
Swarnava Garai, Shri Kant, R. Bahadur· Journal of Structural Biolog...· 0 citations
HyLnc demonstrates that integrating deep contextual representations with biologically interpretable features enhances lncRNA prediction, and provides a robust and scalable solution for large-scale transcriptome annotation and can be extended to other sequence-based prediction.
Amrit Venkatesan, Prashasti Sinha, J. Basak et al.· RNA Biology· 1 citation
A systems-level view of transcriptomic dysregulation across major neurodegenerative diseases is provided and candidate regulatory interactions and molecular targets for future functional investigation are identified.
Amrit Venkatesan, Prashasti Sinha, J. Basak et al.· bioRxiv· 0 citations
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