Open access
Sep 2026
Telomeric Replication Stress Promotes ALT-Associated Hallmarks in ATRX- and p53-Deficient Cells.
BACKGROUND Most human tumors maintain telomeres through telomerase activation; however, a subset relies on the telomerase-independent mechanism known as Alternative Lengthening of Telomeres (ALT). ALT-positive tumors are frequently characterized by inactivating alterations in ATRX (Alpha Thalassemia/Mental Retardation...
Roberta Amato, Emanuela Micheli, C. Focaccetti et al.
· Frontiers in Bioscience · 0 citations