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R. Binsuwaidan

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Open access Sep 2026

Design, Synthesis and Antihyperglycemic/Antilipidemic Activities of Quinoline-thiazolidine-2,4-dione Hybrid

Background: Type 2 diabetes mellitus (T2DM) and hyperlipidemia are interrelated metabolic disorders that significantly increase cardiovascular risk. Thiazolidinediones are known insulin sensitizers, whereas quinoline derivatives possess diverse pharmacological activities. To explore their complementary activity, we des...

ElShimaa Ahmed Mohamed Abousaada, A. Galal-Khallaf, K. Mohammed-Geba et al. · 0 citations
Open access Aug 2026

Design and Synthesis of Novel Morpholine-Derived Nitrogen-Rich Scaffolds as Multifunctional Anticancer and Antibacterial Agents: Biological Evaluation and Computational Studies

The combined biochemical, cellular, and computational findings support the proposed involvement of the EGFR/PI3K/mTOR signaling pathway in its antiproliferative activity and identify DNA gyrase as a potential antibacterial target.

Hagar S. El-Hema, Esraa M. Adel, W. El-Dougdoug et al. · 0 citations
Open access Aug 2026

Multiclass Machine Learning-Based Discovery of Novel Scaffold Inhibitors Targeting ALK

This integrated ML-to-simulation workflow prioritizes structurally novel candidate hits with predicted ALK inhibitory activity and provides an effective strategy for scaffold discovery and hit prioritization.

M. Haque, Q. M. Jamal, K. Ahmad et al. · 0 citations

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