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Review Open access Sep 2026

Balancing cellular copper levels via the post-translational regulation of copper transport.

Copper (Cu) is essential to life as an enzymatic cofactor, powering a plethora of biological processes. However, cells teeter on a delicate balance where both too much and too little Cu can lead to dysfunction. These risks are exemplified by Menkes disease patients, where Cu deficiency leads to neurodevelopmental delay...

Lauren A. Kirn, R. Burke · 0 citations
Open access Sep 2026

The Hippo signalling pathway regulates the timing of epithelial cell replacement during Drosophila abdominal morphogenesis

ABSTRACT Developmental apoptosis plays an important role in shaping the organs of developing animals, such as occurs during the development of the adult fly abdomen, in which the apoptosis of larval epidermal cells (LECs) is delicately balanced with the proliferation of the presumptive adult epithelial cells. The signa...

Kyle Lyon, Samuel A. Manning, R. Burke · 0 citations

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