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Author

R. Businger

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Open access Aug 2026

HIV-1 promotes loss of CD4+ T cell stemness and enrichment of effector-like states via Vpr-mediated TCF7 degradation

Vpr-mediated TCF7 depletion couples enhanced viral fitness to reprogramming of CD4+ T cell identity, generating permissive differentiated cells while impairing the maintenance of effective antiviral immunity via reduced T cell stemness.

Johanna Leyens, Anthea Darius, Carlos Alberto Vanegas-Torres et al. · 0 citations