Author

R. Butler

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Open access Sep 2026

Tissue-wide metabolic buffering confers resilience to mitochondrial dysfunction

Mitochondria and oxidative phosphorylation (OxPhos) are essential for cellular homeostasis. However, the phenotypes caused by mitochondrial dysfunction often display remarkable tissue-specificity. What determines the susceptibility of individual cells to metabolic or mitochondrial defects in a complex in vivo tissue co...

S. Petridi, Abhilesh Dhawanjewar, Dnyanesh Dubal et al. · bioRxiv · 0 citations

Open access Jul 2026

Combinatorial screening of biological degrader modules identifies heterobifunctional molecules that efficiently destroy MYC, leading to rapid tumour cell death in vitro and in vivo

Targeted protein degradation is a potent strategy against intracellular proteins impervious to traditional drugs. We describe a platform reliant on high-throughput cloning and mRNA-based delivery to quickly screen 100s-1000s of modular biological degraders, which we challenge against the high-turnover c-Myc oncoprotein...

C. Ascanelli, Samuel Gilberto, C. Batho et al. · bioRxiv · 0 citations