R. C. Dale

Anti-inflammatory and phosphorylation effects of CFTR modulator triple therapy in cystic fibrosis

Summary CFTR modulators like elexacaftor-tezacaftor-ivacaftor (ETI) improve morbidity in cystic fibrosis (CF), but their systemic effects on young children are not yet clear. We hypothesize that ETI has anti-inflammatory effects and reverse disease-associated molecular signatures in children with CF. This exploratory p...