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Open access Sep 2026

Evaluating and comparing the signalling and functional landscape of hiPSC-CMs derived from patients with dilated cardiomyopathy

Non-ischaemic or dilated cardiomyopathy (DCM) is characterised by abnormal enlargement of the left ventricle, compromising the ability of the heart to pump blood to the body. All patients with DCM are offered the same treatment regimen regardless of individual differences, with highly variable results on disease progre...

Giada Castagnola, Diego Loggia, Kyla Bourque et al. · 0 citations
Open access Jul 2026

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

A functional HOC model using patient‐specific human induced pluripotent stem cells (hiPSCs), reprogrammed from the patients’ blood samples is developed, revealing arrhythmia‐like behavior in DCM tissue and highlighting functional hallmarks of the disease.

Ali Mousavi, Ludovic Mouttet, Shihao Cui et al. · 0 citations

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