Author

R. Chakraverty

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Open access Sep 2026

A combined program of induced stemness and differentiation in response to IFNγ drives acute myeloid leukaemia growth

How inflammation shapes acute myeloid leukaemia (AML) has come under scrutiny, as it may explain the disease’s resistance to immunotherapy approaches. IFNγ has emerged as a key cytokine with paradoxical roles in suppressing and supporting AML growth, and the fundamental question of how leukemic stem cells (LSCs) respon...

C. Pospori, A. Donada, Helena Boutzen et al. · bioRxiv · 0 citations

Open access Aug 2026

Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion.

The dynamic population response to tuning of T cell mTORC1 and the need to separately appraise cellular outputs of therapeutic CD4+ versus CD8+ T cells when metabolic pathways are manipulated by the same method are demonstrated.

F. Sillito, Elisa Armbrecht, A. O'Neill et al. · Journal of Immunology · 0 citations