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Author

R. Chaligné

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Open access Sep 2026

Systemic iron sequestration restricts the intratumoral CD8+ T cell landscape in pancreas cancer

Systemic iron sequestration occurs frequently in cancer due to inflammation-driven expression of the iron-regulatory hormone hepcidin. The impact of systemic iron availability on tumoral immunity is unclear. Here, we show that elevated serum hepcidin is associated with reduced survival and decreased intratumoral CD8+ T...

J. Schoenfeld, Jahi J. Noel, Christopher S. McGinnis et al. · 0 citations
Open access Sep 2026

Type 1 interferon perturbates clonal competition by reshaping human blood development.

Inflammation accelerates evolutionary dynamics of hematopoietic stem cells (HSCs) in clonal hematopoiesis and myeloid neoplasms. We studied HSCs, progenitors and immune cells from patients with myeloproliferative neoplasms at baseline and following interferon-α (IFNα) treatment, the only therapy to deplete mutated stem...

Chhiring Lama, Danielle Isakov, Shira Rosenberg et al. · 0 citations
Open access Jul 2026

IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development

A pro-tumorigenic IL-1β/IL-6 signaling circuit mediated through local macrophages and fibroblasts is identified that unleashes the full oncogenic potential of a cancer driver activated at the PIN stage, with implications for TME-specific targeted therapeutics in early-stage disease.

Young-Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz et al. · 0 citations

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