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Review Open access Oct 2026

Emerging therapeutic strategies and clinical trials in severe asthma management: current evidence and future directions.

INTRODUCTION Biologic therapies have transformed the management of severe asthma, particularly in type 2-high disease, but important unmet needs remain. Incomplete responses, uncertainty in treatment positioning, and the lack of effective options for non-type 2 or mixed inflammatory endotypes continue to limit the achi...

R. Poto, R. Chan, G. Paoletti et al. · 0 citations
Review Aug 2026

Impact and management of biologic therapies on small airway dysfunction in severe asthma: a comprehensive review.

INTRODUCTION Despite significant advances in precision medicine, managing severe asthma remains a major clinical challenge. Small airway dysfunction (SAD) is a crucial determinant of poor symptom control, airway remodeling, and frequent exacerbations. While conventional spirometry primarily assesses large airway mechan...

F. Menzella, R. Chan, M. Cottini et al. · 0 citations

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