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Sep 2026

Synthesis and Application of 3,3-Difluoro Sialic Acid as a Sialyltransferase and Neuraminidase Inhibitor

Sialic acid (Neu5Ac) is a monosaccharide terminating glycoconjugates, serving as ligands for lectins in health and disease. Tools to target sialyltransferases (STs) and neuraminidases (NEUs) are important in the study of sialoglycans. 3FaxNeu5Ac is a common ST inhibitor, while 2,3diFNeu5Ac is a covalent mechanism-bas...

Dhanraj Kumawat, Taylor E. Gray, E. I. Alvarado Melendez et al. · 0 citations
Sep 2026

A Two-Step Synthesis of Covalent Genetically Encoded Libraries of Peptide-Derived Macrocycles Enables the Use of Electrophiles with Diverse Reactivity

Genetically encoded libraries of peptide-derived macrocycles containing electrophile “warheads” (cGELs) can be used to identify potent and selective covalent ligands for protein targets. Such cGELs are synthesized either by incorporation of unnatural amino acids that display mild electrophiles on their side chains or...

James H. Walker, Arunika I. Ekanayake, Nichole J. Pedowitz et al. · 0 citations

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