R. E. MacPherson

Metabolic Shifts Precede Cognitive Decline in the Male hAß‐KI Alzheimer's Mouse Model

A major barrier in AD research is the lack of animals that recapitulate sporadic AD, which accounts for most human cases. Recently, a novel mouse model (hAβ‐KI) was developed by introducing a three‐point mutation that humanizes the beta‐amyloid peptide. These mice exhibit age‐dependent cognitive decline and beta‐amyloi...