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Open access Aug 2026

Group sequential designs and a sample size reestimation approach for partially nested trials

Randomized controlled trials are the gold standard for evaluating interventions. For individually randomized trials, clustering can exist in the intervention arm but not the control arm when the intervention is delivered by study personnels and/or in a group setting. This results in a partially nested design, whi...

Kim May Lee, Aritra Mukherjee, R. Emsley · 0 citations
Review Open access Aug 2026

The extent of Patient and Public Involvement and Engagement in Sequential Multiple Assignment Randomised Trials: A scoping Review.

PPIE reporting in SMARTs is inadequate, which hinders efforts to advance this design and develop acceptable interventions, and it is recommended that researchers embed and comprehensively report PPIE using frameworks such as GRIPP2-SF, that funders require and monitor it, and that journals implement the new CONSORT 202...

Isaac J. Egesa, Faye D. Baldwin, M. Wells et al. · 0 citations

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