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Author

R. Faramand

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Open access Aug 2026

IFN-γ-driven iNOS induction in macrophages mediates CAR T cell resistance in B cell lymphoma

Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but many patients with large B cell lymphoma (LBCL) experience primary resistance or relapse. To uncover resistance mechanisms, here we examine pre-infusion tumor biopsies and observe that increased immunoregulatory macrop...

SaeBom Lee, A. Pavy, Nolan J. Beatty et al. · 0 citations
Open access Jul 2026

A novel severe toxicity-free, and progression-free survival endpoint predicts outcomes after CD19 chimeric antigen receptor-T cell therapy in large B-cell lymphoma.

TPFS6 remained prognostic for OS and PFS even after accounting for PD/SD, underscoring the impact of severe toxicity on subsequent survival, and may predict long-term outcomes following CAR-T therapy.

A. Saha, Junmin Whiting, R. Mohty et al. · 0 citations

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