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Open access Aug 2026

CD24 Acts as an Evolutionarily Conserved Innate Immune Checkpoint in Colorectal Cancer

Checkpoint immunotherapy has transformed cancer treatment, yet current approaches targeting adaptive immunity benefit only a subset of patients, leaving innate immunity as a largely untapped therapeutic frontier. Here, we identify CD24 as an innate immune checkpoint that protects colorectal tumors from macrophage-media...

A. Machado, Cátia Rebelo de Almeida, Catarina M. Azevedo et al. · 0 citations
Open access Sep 2026

Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression.

Phagocytic synapse enhancers are developed, a class of modular immune engagers comprising a high-affinity PD-L1 binder coupled to a macrophage-stimulating peptide, tuftsin, that provides a blueprint for a plug-and-play platform of immune engagers targeting diverse cancer-associated pathways.

Valerio Sabatino, Cong Tang, Rita C. Acúrcio et al. · 0 citations

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