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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

R. Fukui

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Open access Oct 2026

Extracellular RNA clearance by non-canonical cell-surface MDA5 protects against lung fibrosis

The role of innate immune receptors, specifically RNA sensors, in non-pathogen-driven lung fibrosis remains unclear. Here, we demonstrate that the cytosolic RNA sensor MDA5 could translocate to the cell surface upon bleomycin-induced damage. MDA5-deficient mice exhibited exacerbated lung fibrosis with increased IL-17A⁺...

T. Ishii, Masafumi Horie, H. Urushiyama et al. · 0 citations
Oct 2026

Toll-like receptors 7 and 8 as therapeutic targets for human diseases.

Toll-like receptor 7 (TLR7) and TLR8 respond to pathogen-derived single-stranded RNA (ssRNA), orchestrating innate immune defense responses upon infections. However, aberrant recognition of endogenous ssRNAs by these sensors can cause various pathologies, including systemic lupus erythematosus (SLE), familial histiocyt...

R. Fukui, Kensuke Miyake · 0 citations

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