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Open access Dec 2025

Engineering a ribozyme with aminoacyl-tRNA synthetase activity

A ribozyme that can charge a tRNA with amino acids and discriminate between cognate and non-cognate tRNAs is of interest because an RNA with this ability may have been a critical for translation in the transition from the RNA world. In addition, it could provide a tool for incorporating non-canonical amino acids for bi...

R. Gan, Ji Chen, Gerald Manuel et al. · 0 citations
Open access Aug 2026

Single-cell multi-omics reveals circulating B cell heterogeneity across diverse disease contexts

Introduction B cells play essential roles in adaptive immunity by producing antigen-specific antibodies and interacting with T cells. Single-cell RNA and BCR sequencing technologies have enabled high-resolution dissection of B cell heterogeneity across diverse disease contexts. Atypical B cells (ABCs) display complex a...

R. Gan, Y. Zhong · 0 citations

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