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R. Gillis

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Case report Open access Aug 2026

Emergence of EGFR C797S as a resistance mechanism to CLN081 in EGFR exon 20–mutant NSCLC: case report

EGFR exon 20 insertion mutations represent a distinct subset of non–small cell lung cancer (NSCLC) with limited sensitivity to earlier-generation EGFR tyrosine kinase inhibitors (TKIs). CLN081 (zipalertinib; TAS6417) is a novel covalent EGFR TKI under development with activity against EGFR exon 20 insertion variants. W...

Basil Dabbah, R. Gillis, Jaber Salim et al. · 0 citations

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