Synthesis of novel disubstituted tetrazole scaffolds via the Ugi TMS-N3 reaction and their antimicrobial evaluation molecular docking and ADME profiling
The design and synthesis of ten disubstituted tetrazole derivatives (5a–5j) via a one-pot, four-component Ugi-azide reaction (UGI-4CR) employing 2-(4-chloro-2-formylphenoxy)acetonitrile, variously substituted primary aromatic amines, trimethylsilyl azide, and tert-butyl isocyanide in anhydrous methanol at ambient tempe...