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Preprint Sep 2026

Computationally Efficient Pathology Segmentation using Knowledge Distillation from Foundation Models

Automatic tissue segmentation is essential for large-scale analysis of histopathology whole-slide images (WSIs), but accurate pixel-level segmentation remains challenging. Pixel-level annotations are expensive to obtain, models pre-trained on natural images may transfer poorly to histopathology, and pathology foundatio...

Jia-Qi Lv, Yi-Jie Zhu, Saki Okada et al. · 0 citations
Open access Aug 2026

A microbiota-responsive polyfunctional cytotoxic CD4⁺ T-cell state promotes mucosal inflammation in ulcerative colitis

Ulcerative colitis (UC) is characterised by chronic colonic inflammation with marked heterogeneity in disease severity and therapeutic outcomes. Here, we define a spatially organised, polyfunctional cytotoxic CD4⁺ T-cell state associated with mucosal inflammation and adverse therapeutic outcomes in UC. Integrating ex v...

John P Thomas, S. H. Kottoor, Jonathan W. Lo et al. · 0 citations

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