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Author

R. Gronostajski

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Sep 2026

Temporal regulation of progenitor lineage progression and output by NFIs underlying human neocortical malformation.

Nuclear factor I (NFI) misexpressions in humans are associated with severe brain malformations, yet the underlying mechanisms remain poorly understood. Here, we show that NFIs regulate the broad lineage progression and lifespan of radial glial progenitors (RGPs), thereby bidirectionally controlling neocortical developm...

Qiang-Qiang Zhang, Guo-Hua Yuan, E. Albizzati et al. · 0 citations
Aug 2026

Astrocytic NFIX regulates thalamocortical circuits through GABA and purinergic signaling.

These studies identify region-specific roles for astrocytic NFIX and its gene regulatory network in TRN astrocytes, while further revealing that astrocytes in the TRN couple regulation of thalamocortical circuit dynamics and memory formation through parallel GABA and purinergic signaling pathways.

Sanjana Murali, Manuel Silva-Pérez, Jun-Sung Woo et al. · 0 citations

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