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Author

R. Houlston

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Open access Sep 2026

Massively parallel functional profiling prioritizes breast cancer risk variants and implicates CCDC88C in ER-positive breast cancer

This work identified 709 variants mapping to 140 risk regions, that are associated with significant variation between REF and ALT alleles, that may influence breast cancer risk through expression of CCDC88C, which in turn could impact prognosis.

Kate Mackie, H. Kemp, A. Gunnell et al. · 0 citations
Review Open access Jul 2026

Moving beyond the neutral-Darwinian dichotomy to inform precision oncology.

It is argued that tumour evolution is not a binary state, but a dynamic continuum shaped by genetic and non-genetic heterogeneity, spatial constraints, microenvironmental pressures and therapeutic bottlenecks, which will align these models with therapeutic decision-making in precision oncology.

A. Sud, R. Houlston · 0 citations

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