Author

R. J. Keenan

2 papers indexed here

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Open access Oct 2026

Optimization of Search and Acquisition Strategies for DSSO Crosslinking Mass Spectrometry using Protein Prospector and Touchstone

Crosslinking mass spectrometry (XL-MS) enables residue-level characterization of protein-protein interactions (PPIs) in both purified assemblies and complex biological systems. Cleavable crosslinkers such as DSSO are widely used to facilitate analysis of complex samples, yet there remains limited consensus on how best...

M. Trnka, Clinton Yu, Peter R. Baker et al. · bioRxiv · 0 citations

Open access Sep 2026

Cotranslational membrane protein biogenesis by an EMC-bound translocon.

Secretory and membrane protein biogenesis occurs at ribosome-bound translocons in the endoplasmic reticulum (ER) membrane. Translocons consist of the Sec61 protein-conducting channel and various maturation factors including chaperones, modification enzymes and membrane insertases, which assemble dynamically in response...

Madeline G. Rollins, Josephine Tang, Yu Wan et al. · Nature Structural & Molecula... · 0 citations