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Author

R. Ketting

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Open access Sep 2026

A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation

Robust RNA interference in Caenorhabditis elegans requires Argonaute-targeted RNAs to be cleaved by RDE-8 and poly(UG)ylated by MUT-2, generating templates for RNA-dependent RNA polymerases that synthesize secondary small RNAs. RDE-8 and MUT-2 are physically coupled within the cleavage and poly(UG)ylation (CPUG) comple...

V. Busetto, M. Brehm, Annamaria Sgromo et al. · 0 citations

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