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Author

R. Kirchdoerfer

2 papers indexed here

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Open access Sep 2026

The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism.

These findings establish a two-pronged mode of coronavirus polymerase inhibition by CMX521, and suggest a second inhibitory mechanism for CMX521 when the coronavirus polymerase is associated with the viral helicase.

Asif Rakib, Calvin J. Gordon, Thomas K. Anderson et al. · 0 citations
Open access Aug 2026

Structural and biochemical analysis of the IBV nsp15 endoribonuclease reveals the necessity of peripheral site residues for activity

Infectious bronchitis virus (IBV) is a member of the Gammacoronavirus genus responsible for respiratory illness and weakened eggshells in infected chickens, adversely impacting the poultry industry. Escaping innate immune detection during infection is crucial for coronavirus proliferation in the host. The production of...

Ena S. Tully, R. Kirchdoerfer · 0 citations

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