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R. Knight

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Open access Sep 2026

Genome-resolved ecology and evolution of the microbiome enabled by quantitative long-read metagenomics

Standard metagenomics resolves microbial communities only in relative terms and at coarse taxonomic resolution, obscuring how individual strains change in absolute abundance and evolve within a host1–6. We present long-read quantiomics (LRQ), a quantitative metagenomics platform coupling long-read sequencing with plasm...

M. O. Din, C. Brennan, Jian-Shu Zhao et al. · 0 citations
Open access Aug 2026

Joint-RPCA: domain-aware multi-omics integration for systems microbiology.

Joint Robust Principal Component Analysis (Joint-RPCA), a method designed with these statistical properties in mind and broadly applicable to multi-omics settings with similar challenges, reveals replicable and interpretable multi-omic patterns.

Bianca Cordazzo Vargas, C. Martino, A. Dilmore et al. · 1 citation

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