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Open access Sep 2026

Are the factors associated with cognitive performance generalizable across cohorts?

OBJECTIVE To examine whether vascular risk and brain atrophy account for cohort differences in the associations between tau burden and cognition across cognitive domains in U.S. POINTER and ADNI. METHODS We analyzed baseline data from 775 U.S. POINTER and 405 ADNI participants without significant cognitive impairment...

Pei-Wei Liu, Theresa M. Harrison, H. Snyder et al. · 0 citations
Open access Aug 2026

EOAD-Signature Atrophy Predicts Dementia in Early-Onset MCI due to Alzheimer Disease

Background and Objectives Early-onset Alzheimer disease (EOAD) is associated with substantial variability in clinical progression, and reliable biomarkers to predict the transition from mild cognitive impairment (MCI) to dementia remain limited. Structural MRI measures have demonstrated prognostic value in late-onset A...

T. Paranhos, Yuta Katsumi, M. Brickhouse et al. · 0 citations
Open access Jul 2026

Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.

A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).

G. Blazhenets, D. Soleimani-Meigooni, Konstantinos Chiotis et al. · 5 citations

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