Both host genetics and environmental exposures shape the salivary microbiota; however, the relative contributions of these factors from early life to adulthood remain unclear. To address this, we profiled the salivary microbiota of 3387 twin pairs: 939 infant pairs (9–12 months) and 2,448 adult pairs (23–52 years) usin...
Simon Haworth, E. Bellou, R. Kuja-Halkola et al.· npj Biofilms and Microbiomes· 0 citations
Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of (1) ADHD and (2) ADHD medication use with rates of major adv...
Zi-Han Dong, Yi-Ling Zhou, Hong-Hui Yao et al.· BMC Medicine· 0 citations
Substance use disorders (SUD) are associated with suicidal behaviour, but less is known regarding the extent to which familial factors influence these associations across different types of SUD. We performed a national register study including 4,209,615 individuals born in Sweden 1958-1999 and followed 1973-2020. Expos...
L. Khemiri, R. Kuja-Halkola, Henrik Larsson et al.· Molecular Psychiatry· 0 citations
Findings support a multifactorial model of AN involving individual-specific influences and shared familial liability, and suggest that several clinical and phenotypic features may reflect familial liability for AN.
Hunna J. Watson, Elisabeth Welch, Elin Monell et al.· European eating disorders re...· 0 citations
It is demonstrated that ADs share substantial cluster-specific genetic overlap that largely aligns with affected tissue types, leading to distinct groupings of connective tissue diseases, gastrointestinal disorders, and endocrinopathies, whereas diseases of the nervous system show limited genetic cohesion.
Daniel Eriksson, R. Kuja-Halkola, M. Holmqvist et al.· Journal of Clinical Investig...· 0 citations
The findings suggest that, rather than recommending fixed first-line and second-line treatments for individuals with ADHD-ASD, clinical guidelines should emphasise appropriate training as well as prompt and individualised treatment based on a shared decision-making process.
M. Garcia-Argibay, R. Kuja-Halkola, B. D'Onofrio et al.· BMJ mental health· 0 citations
Individuals with childhood-onset T1D and their full siblings had higher odds of recorded NDC diagnoses, and these findings support access to neurodevelopmental expertise in paediatric diabetes services.
Sheng-Xin Liu, G. Machado, Irzam Hardiansyah et al.· Acta paediatrica· 0 citations
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