Author

R. LaJoie

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Open access Oct 2026

Too early for LATE? Age at onset is associated with the clinical and neuroimaging expression of limbic-predominant age-related TDP-43 pathology in Alzheimer's disease

Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) frequently co-occurs with Alzheimer's disease (AD) pathology and has been studied mainly in older populations. We examined its frequency and expression in 196 individuals with autopsy-confirmed intermediate-to-high AD neuropathologic...

N. Zhu, R. LaJoie, I. Allen et al. · medRxiv · 0 citations

Oct 2026

Quick Conclusions From Slowed Saccades: When Progressive Supranuclear Palsy Overshadows Lewy Body Disease

Antemortem prediction of dementia-causing neurodegenerative disease is challenging, in part due to the frequency of co-occurring diseases. Etiologic diagnosis may be aided by the identification of highly specific clinical features or available biomarkers. Here we present an educational case of an individual with a prim...

D. L. Fischer, M. Sanderson-Cimino, W. Seeley et al. · Cognitive and Behavioral Neu... · 0 citations

Open access Oct 2026

Large-scale cerebrospinal fluid proteomics identifies diagnostic biomarker candidates across the clinico-pathological continuum of frontotemporal lobar degeneration

Frontotemporal lobar degeneration (FTLD), predominantly comprised of tau and TDP-43 proteinopathies, is a common cause of early-onset dementia. Biomarkers that reliably classify FTLD subtypes are limited, thereby hindering in-vivo diagnosis and clinical trial stratification. We conducted large-scale, multi-platform cer...

R. Saloner, L. Cornelis, Joshua Downer et al. · bioRxiv · 0 citations