Open access
Sep 2026
Early emergence of contractility and mechanotransduction during human megakaryopoiesis
Abstract The ability to contract blood clots is a hallmark of functional platelets. Proteins that support agonist-induced platelet contraction are expressed in megakaryocytes (MKs) and transferred to platelets during thrombopoiesis. Here, we investigated when during MK development the functional machinery for contracti...
Oleg V. Kim, R. Litvinov, Deborah L. French et al.
· Research Square · 0 citations