Author

R. Lokey

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Open access Jul 2026

Massively Parallel, Single-Molecule Assessment of Synthetic Fidelity and Drug-Like Properties in a DNA-Encoded Library.

DNA-encoded libraries (DELs) are powerful drug discovery tools, enabling rapid hit generation against immobilized protein targets. However, translating these hits is often hampered by synthetic inefficiency and, for libraries of "beyond-Rule-of-5" compounds such as macrocyclic peptides, by enrichment of poorly cell-per...

Grant Koch, M. F. Lawler, Adam Murray et al. · Journal of Medicinal Chemist... · 0 citations

Open access Mar 2026

Minimal N-methylated and stapled peptide inhibitors of the autophagy protein GABARAP

The LC3/GABARAP protein family is a promising target for selective inhibition of autophagy. Further, LC3/GABARAP ligands have been used as targeted degraders of soluble proteins, protein aggregates, mitochondria, lipid droplets, and RNA. However, the small molecules used for such applications have poor binding affinity...

Imani McDonald, Joana A. Wilms, Nicholas Cardi et al. · bioRxiv · 0 citations