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R. Lucaciu

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Review Open access Oct 2026

Lipid Metabolism and Ferroptosis in Cancer: Regulatory Mechanisms, Alternative Splicing, and Therapeutic Implications

Ferroptosis is an iron-dependent form of regulated cell death driven by phospholipid peroxidation and is increasingly recognized as an important vulnerability in cancer. Its sensitivity is determined by the interplay between membrane lipid composition, iron availability, oxidative stress, and antioxidant defense. Cance...

L. Procopciuc, Adrina Corina Hangan, R. Lucaciu · 0 citations
Review Open access Sep 2026

Targeting Aromatase and HDACs in Hormone Receptor-Positive Breast Cancer: Molecular Interplay, Endocrine Resistance and Therapeutic Opportunities

Breast cancer is the most frequently diagnosed malignancy in women, and hormone receptor-positive disease represents its predominant subtype. Aromatase inhibitors (AIs) are a cornerstone of endocrine therapy, particularly in postmenopausal patients, but their long-term efficacy is frequently limited by intrinsic or acq...

R. Lucaciu, Adrina Corina Hangan, L. Oprean et al. · 0 citations
Review Open access Sep 2026

The Tryptophan–Kynurenine Pathway as a Key Mediator of the Gut–Brain Axis in Depression and Alzheimer’s Disease

Depression and Alzheimer’s disease are among the most prevalent and disabling disorders worldwide, imposing a substantial social, economic, and healthcare burden. Increasing evidence suggests that these conditions share several pathophysiological mechanisms, including chronic inflammation, oxidative stress, mitochondri...

L. Procopciuc, Adrina Corina Hangan, Sidonia Gog-Bogdan et al. · 0 citations
Open access Aug 2026

Oxidative Stress Biomarkers and Their Association with Interleukin-6 in Patients with Obstructive Sleep Apnea: A Cross-Sectional Study

Oxidative stress and systemic inflammation are considered key mechanisms linking obstructive sleep apnea (OSA) to cardiovascular disease. This study aimed to investigate the relationships among oxidative stress, nitrosative stress, inflammatory biomarkers, and echocardiographic alterations in OSA. This cross-sectional...

Crina Veronica Zinveliu Bercian, D. Măgureanu, R. Pop et al. · 0 citations

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