Author

R. Madsen

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Open access Oct 2026

The mTOR pathway drives daily physiology

How molecular clocks drive daily rhythms in mammalian physiology remains poorly understood. Here we show that the mechanistic target of rapamycin (mTOR) pathway is required for most daily variation in cellular and organismal physiology. PERIOD2 binds to mTORC1 and limits its activity, providing a route by which the clo...

Aiwei Zeng, A. Mihut, M. Anandapadamanaban et al. · bioRxiv · 0 citations

Open access Sep 2026

Genetic and pharmacologic inhibition of Keap1 dampens the pro-fibrotic program in human hepatic stellate cells

The increasing prevalence of chronic liver diseases (CLDs) is a global health concern. CLDs can cause fibrosis, and there is an urgent need for antifibrotic agents. The primary driver of fibrogenesis, transforming growth factor beta 1 (TGF-β1), activates hepatic stellate cells (HSCs), which are responsible for hepato...

Sharadha Dayalan Naidu, R. Madsen, Boushra Bathish et al. · Scientific Reports · 0 citations