Author

R. Manguso

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Open access Oct 2026

A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy

Genetically modified immune effector cells, including chimeric antigen receptor (CAR) T cells, have emerged as transformative anti-cancer agents. However, these autonomous, living therapies are limited by difficult-to-control hyperactivation toxicities. To achieve their full potential as therapies for a broader range o...

Ditsa Sarkar, William Lin, Nelson H. Knudsen et al. · bioRxiv · 0 citations

Oct 2026

Epigenetic Priming Sensitizes Metastatic Breast Cancer to Checkpoint Blockade by Rewiring the Tumor-Immune Microenvironment.

Immune checkpoint blockade (ICB) has shown limited efficacy in metastatic breast cancer. Resistance mechanisms involve suppressive myeloid and stromal populations in the tumor microenvironment (TME). In this issue of Cancer Research, Gonzalez and colleagues integrate single-cell transcriptomics, spatial proteomics, fun...

Yaiza Senent, R. Manguso · Cancer Research · 0 citations

Jul 2026

CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer.

These findings highlight Dusp5 and Zfp219 as critical drivers of age-related T cell dysfunction that can be targeted to rejuvenate antitumor immunity in older cancer patients.

Alex C. Y. Chen, Keely Y. Ji, C. Yerinde et al. · Cell · 0 citations