Epigenetic clocks are widely applied biomarkers of biological age, but their biological underpinnings remain unclear. We previously showed that epigenetic clocks are affected by naïve and memory T cell proportions, suggesting blood cell composition as a potential driver. However, analysis of cell composition is complic...
Thomas H. Jonkman, Anne Richmond, R. Marioni et al.· Genome Medicine· 0 citations
ABSTRACT Ageing biomarkers quantify molecular, physiological or functional features that vary between individuals as they age and may improve prediction of health outcomes beyond chronological age. Recently, plasma proteomics have been used to estimate the biological ages of 11 human organs. Although accelerated organ...
M. Pyrgioti, I. Eguiagaray, P. Redmond et al.· Aging Cell· 0 citations
Age-related changes in the mean or variance of DNA methylation (DNAm) at individual CpG sites are well established. However, CpGs that share biological functions often exhibit coordinated regulation. Here, we analysed whole-blood DNAm data from over 7,500 individuals and identified modules of co-methylated CpGs that ei...
E. Cheruiyot, A. Hatton, Daniel L. McCartney et al.· bioRxiv· 0 citations
Recent lifespan frameworks of aging theorize that pubertal development and cellular aging are governed by overlapping pathways, but the time lag between adolescence and older adulthood complicates the study of shared molecular mechanisms. Here we compare a DNA-methylation-based epigenetic index of pubertal development...
Q. Wu, S. Gibbs, A. deSteiguer et al.· medRxiv· 0 citations
The integration analysis showed that genetic variants and DNA methylation at sites annotated to the FADS gene cluster were linked with lipid species that were also associated with lifetime MDD status, while introducing DNA methylation as an additional molecular layer supporting this link.
H. Smith, A. Richmond, M. Adams et al.· medRxiv· 0 citations
Findings support cg05917797 as a reproducible blood-based epigenetic marker of long-term dementia risk and higher methylation at cg05917797 was associated with lower Braak stage in temporal gyrus and cerebellum.
A. Maihofer, C. Mackey, J. Robertson et al.· medRxiv· 0 citations
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