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Author

R. Marschalek

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Open access Jul 2026

Influence of IGF2BP3 on t(4;11) fusion mRNA and protein abundance.

The data indicate that MA4 alone drives aberrantly high expression of only a few target genes, whereas A4M counteracts this detrimental effect, and suggests that A4M is crucial through its chromatin-opening activity, which strongly expands the pool of MA4 target genes and thereby promotes the establishment of pre-leukemogenic and leukemogenic gene expression programs.

T. Hanewald, T. Benz, R. Marschalek · 0 citations